Rl. Chaiken et al., HYPERFILTRATION IN AFRICAN-AMERICAN PATIENTS WITH TYPE-2 DIABETES - CROSS-SECTIONAL AND LONGITUDINAL DATA, Diabetes care, 21(12), 1998, pp. 2129-2134
OBJECTIVE - Hyperfiltration may play a role in the development of diab
etic nephropathy African-American patients with diabetes have more tha
n a fourfold increase in end-stage renal disease. The purpose of this
study is to evaluate the impact of hyperfiltration on renal function i
n African-American patients with type 2 diabetes. RESEARCH DESIGN AND
METHODS - Renal function of 194 African-American patients with diagnos
ed type 2 diabetes from 1 month to 36 years was assessed by studies of
isotopic glomerular filtration rate (GFR), serum creatinine, creatini
ne clearance, and 24-h urinary albumin excretion rates. Thirty-four pa
tients with a duration of diagnosed type 2 diabetes from 1 month to 10
years were found to have hyperfiltration (GFR greater than or equal t
o 140 ml . min(-1) . 1.73 m(-2)). Fifteen of these patients received l
ongitudinal follow-up of renal function for as long as 15 years after
the initial study. RESULTS - Hyperfiltration is present in 15 (36%) of
42 patients whose duration of diagnosed type 2 diabetes is <1 year, a
nd it persists for up to 10 years in 14-20% of patients with diagnosed
type 2 diabetes. Patients with hyperfiltration are younger than their
counterparts without hyperfiltration when matched for duration of dia
gnosed diabetes. When followed over time, those patients with hyperfil
tration were not more likely to develop impaired renal function as mea
sured by GFR or creatinine clearance. CONCLUSIONS - Hyperfiltration do
es not identify patients at risk for deterioration in renal function.