STUDIES OF ALOE - VI - CATHARTIC EFFECT OF ISOBARBALOIN

Citation
Y. Ishii et al., STUDIES OF ALOE - VI - CATHARTIC EFFECT OF ISOBARBALOIN, Biological & pharmaceutical bulletin, 21(11), 1998, pp. 1226-1227
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy
ISSN journal
09186158
Volume
21
Issue
11
Year of publication
1998
Pages
1226 - 1227
Database
ISI
SICI code
0918-6158(1998)21:11<1226:SOA-V->2.0.ZU;2-4
Abstract
The cathartic effect of isobarbaloin, a stereoisomer of barbaloin (com pound principally responsible for the cathartic activity of Aloe), was examined in male rats by oral administration. Individual differences in sensitivity in the laxative activity of isobarbaloin and barbaloin was not found. The cathartic activity (ED,,) of isobarbaloin in barbal oin positive rats was 19.2 mg/kg, nearly equal to that of barbaloin (1 9.5 mg/kg). Also, isobarbaloin administered orally was demonstrated to decompose to aloe-emodin-9-anthrone (active metabolite of barbaloin) as well as to barbaloin. Therefore, it is considered that the mechanis m underlying the cathartic effect of isobarbaloin is the same as that of barbaloin.