INHIBITION OF POLYPOSIS IN THE SMALL-INTESTINE OF BALB C MICE BY INTESTINAL BACTERIA/

The incidence of polyposis and the number of polyps per mouse were sig nificantly lower in conventionalized (CVz) mice than in germ-free (GF) mice. There was no significant difference in the average number of po lyps between GF and gnotobiotic (GB) mice monoassociated with the vari ous strains of intestinal bacteria. However, the incidence of polyposi s and the number of polyps per mouse were significantly lower for mice associated with either chloroform-resistant bacteria (CRB) or fusifor m bacteria (FB) than for GF mice This study demonstrated that polyposi s was suppressed by FB and CRB in the small intestine of BALB/c mice. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.