ANGIOGENESIS INDUCED BY UROTHELIAL CELLS (HCV-29) AND THEIR V-RAS ANDV-RAF TRANSFECTANTS

Authors
PRZYBYSZEWSKA M MILOSZEWSKA J JANIK P
Citation
M. Przybyszewska et al., ANGIOGENESIS INDUCED BY UROTHELIAL CELLS (HCV-29) AND THEIR V-RAS ANDV-RAF TRANSFECTANTS, Cancer letters, 131(2), 1998, pp. 157-161
Citations number
17
Categorie Soggetti
Oncology
Journal title
Cancer letters → ACNP
ISSN journal
03043835
Volume
131
Issue
2
Year of publication
1998
Pages
157 - 161
Database
ISI
SICI code
0304-3835(1998)131:2<157:AIBUC(>2.0.ZU;2-H
Abstract
The angiogenic ability of human urothelial cells (HCV-29) and their v- ras and v-raf transfectants was studied. The most pronounced angiogene sis, observed in vivo, induced v-raf-transfected cells. The lowest deg ree of induction of neovascularization presented cells of the parental line; The increased extent of angiogenesis correlated with the presen ce of VEGF mRNA as measured by RT-PCR as well as the level of VEGF as visualized by the method of Western blotting. (C) 1998 Elsevier Scienc e Ireland Ltd. All rights reserved.