EFFECTS OF CP-060S, A NOVEL CARDIOPROTECTIVE DRUG, ON CARDIAC-FUNCTION AND MYOCARDIAL OXYGEN-CONSUMPTION

1. We examined the effects of CP-060S on cardiac function and myocardi al oxygen consumption (MVO2) in anesthetized dogs. 2. CP-060S (10-300 mu g/kg IV) decreased heart rate, increased aortic flow and decreased mean blood pressure in a dose dependent manner, The PR interval was si gnificantly prolonged by administration of CP-060S (300 mu g/kg IV): 3 . CP-060S (10-300 mu g/kg IV) increased coronary blood flow in a dose dependent manner. Left ventricular end-diastolic pressure and maximal first derivative of left ventricular pressure were not significantly a ffected. 4. CP-060S (10-300 mu g/kg IV) increased coronary sinus blood flow and decreased arteriovenous oxygen difference and MVO2 in a dose dependent manner. 5. The effects of CP-060S on cardiac function and M VO2 are qualitatively similar to those of diltiazem, a typical Ca2+ an tagonist, (C) 1998 Elsevier Science Inc.