Afe. Rump et al., PSEUDOCHOLINESTERASE-ACTIVITY REDUCTION DURING CARDIOPULMONARY BYPASS- THE ROLE OF DILUTIONAL PROCESSES AND PHARMACOLOGICAL AGENTS, General pharmacology, 32(1), 1999, pp. 65-69
1. Pseudocholinesterase (ChE) activity is a determinant of the elimina
tion kinetics of several drugs used in anesthesia. The time course of
ChE activity was investigated in 16 patients undergoing cardiosurgery
for a cardiopulmonary bypass (CPB) in normothermia or hypothermia. 2.
The onset of the CPB was accompanied by a decrease in ChE activity (-3
7%) (P<0.05) and protein; concentration (-24%) (P<0.05). The quotient
ChE activity/protein concentration was numerically reduced to a smalle
r extent (-15%) (P>0.05). After the CPB was finished, ChE activity and
the protein concentration remained low for the remaining operation ti
me. 3. There was no difference in ChE activity, measured in vitro at 3
7 degrees C, between the normothermic and hypothermic group (P>0.05).
4. There was no correlation between heparin concentration in serum and
reduction of ChE activity in vitro (P>0.05). In vitro, the ChE activi
ty was not affected by either heparin in doses as high as 10,000 U/ml
or aprotinin in doses as high as 10,000 U/ml (P>0.05). 5. Conclusions:
(1) ChE activity is reduced by CPB mainly by hemodilution and (2) the
pharmacological agents used in the present anesthetic technique (hepa
rin, aprotinin, midazolam, fentanyl, propofol and mivacurium) do not i
nhibit ChE activity at therapeutic serum concentrations. (C) 1998 Else
vier Science Inc.