SERUM LEVELS OF SOLUBLE INTERCELLULAR-ADHESION MOLECULE-1 (ICAM-1) AND THE EXPRESSION OF ICAM-1 MESSENGER-RNA IN UTERINE CERVICAL-CANCER

Authors
NASU K NARAHARA H ETOH Y KAWANO Y HIROTA Y MIYAKAWA I
Citation
K. Nasu et al., SERUM LEVELS OF SOLUBLE INTERCELLULAR-ADHESION MOLECULE-1 (ICAM-1) AND THE EXPRESSION OF ICAM-1 MESSENGER-RNA IN UTERINE CERVICAL-CANCER, Gynecologic oncology, 65(2), 1997, pp. 304-308
Citations number
37
Categorie Soggetti
Oncology,"Obsetric & Gynecology
Journal title
Gynecologic oncology → ACNP
ISSN journal
00908258
Volume
65
Issue
2
Year of publication
1997
Pages
304 - 308
Database
ISI
SICI code
0090-8258(1997)65:2<304:SLOSIM>2.0.ZU;2-4
Abstract
The purpose of this investigation was to evaluate the serum level of s oluble intercellular adhesion molecule-1 (sICAM-1) in patients with sq uamous cell carcinoma of the cervix. Serum levels of sICAM-1 were meas ured by enzyme-linked immunosorbent assay in patients with cervical ca ncer (stage 0 through IV). Expression of mRNA in tumor tissues was eva luated by reverse transcriptase-polymerase chain reaction. Serum level of sICAM-1 in patients with advanced-stage (II-IV) or recurrent cervi cal cancer was found to be increased significantly. Expression of ICAM -1 mRNA was observed in most tumor tissues. Results suggest that sICAM -1 is shed from the cancerous tissue in patients with. squamous cell c arcinoma of the cervix. (C) 1997 Academic Press.