EFFECT OF ORAL ONDANSETRON CAN TOTAL CHOLECYSTOKININ PLASMA-LEVELS FOLLOWING CCK-4 PANIC CHALLENGE PROCEDURE IN HEALTHY-MEN

Objective: To gain insight into whether ondansetron treatment induces changes in total cholecystokinin (CCKT) plasma levels before and after administration of the cholecystokinin tetrapeptide (CCK-4) panic chal lenge procedure in healthy men. Methods: Thirty-eight volunteers recei ved a 50-mu g bolus of CCK-4 60 minutes after a single oral dose (acut e treatment) and multiple oral doses (chronic treatment) of ondansetro n or placebo. Results: Results showed no difference in CCK, plasma lev els or CCK, elimination rate constant between the ondansetron and the placebo groups after either acute or chronic treatment. Conclusion: Re sults from this study suggest that total CCK plasma levels are not inf luenced by either acute or chronic treatment with ondansetron. However , the effect of ondansetron on the different CCK component fractions s till needs exploration.