SYNTHESIS OF TN, SIALYL TN AND HIV-1-DERIVED PEPTIDE ANTIGEN CONJUGATES HAVING A LIPID-A ANALOG AS AN IMMUNOADJUVANT FOR SYNTHETIC VACCINES

Authors
MIYAJIMA K NEKADO T IKEDA K ACHIWA K
Citation
K. Miyajima et al., SYNTHESIS OF TN, SIALYL TN AND HIV-1-DERIVED PEPTIDE ANTIGEN CONJUGATES HAVING A LIPID-A ANALOG AS AN IMMUNOADJUVANT FOR SYNTHETIC VACCINES, Chemical and Pharmaceutical Bulletin, 46(11), 1998, pp. 1676-1682
Citations number
20
Categorie Soggetti
Chemistry Medicinal",Chemistry,"Pharmacology & Pharmacy
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
46
Issue
11
Year of publication
1998
Pages
1676 - 1682
Database
ISI
SICI code
0009-2363(1998)46:11<1676:SOTSTA>2.0.ZU;2-M
Abstract
Conjugates (3-5) of Tn, sialyl Tn and HIV-1-derived peptide antigen,vi th a N-tetradecanoyl L-serine-beta-alanine-containing D-glucosamine de rivative, structurally related to lipid A, as an immunoadjuvant for th e development of totally synthetic vaccines against cancers or HIV wer e synthesized. The mitogenic activity of compounds 3, 4 and 5 was stro nger than that of lipid A analogs (1, 2).