AUTOLOGOUS PERIPHERAL-BLOOD PROGENITOR-CELL TRANSPLANTATION FOR NON-HODGKINS-LYMPHOMA WITH EXTENSIVE BONE-MARROW NECROSIS

A patient with malignant lymphoma, large cell type and extensive bone marrow necrosis at presentation is reported, Bone marrow necrosis pers isted even after a complete remission was induced with standard chemot herapy, Because of this adverse prognostic factor, circulating stem ce lls were collected and reinfused following a myeloablative regimen con sisting of busulfan, etoposide and cyclophosphamide. The patient engra fted rapidly and a subsequent bone marrow examination was free of both lymphoma and necrosis, To the best of our knowledge, this is the firs t reported patient with extensive bone marrow necrosis in whom circula ting progenitor cells were harvested and utilized successfully.