TRANSFER OF AUTOIMMUNE-THYROIDITIS AND RESOLUTION OF PALMOPLANTAR PUSTULAR PSORIASIS FOLLOWING ALLOGENEIC BONE-MARROW TRANSPLANTATION

We report an unusual case of a patient who was cured of one autoimmune disease (palmoplantar pustular psoriasis (PPP)) but developed another autoimmune disease (autoimmune thyroiditis) after allogeneic BMT. A 4 0-year-old man suffering from AML with PPP underwent allogeneic BMT fr om his HLA-identical sister for the treatment of AML. The patient expe rienced complete clearance of the cutaneous PPP despite the cessation of immunosuppressive therapy for over 2 years, However, he developed h yperthyroidism with anti-thyroglobulin antibodies 5 months after BMT, although he had showed normal thyroid functions without anti-thyroglob ulin antibodies before BMT, The donor had no history of thyroid diseas es and showed normal thyroid functions but was positive for anti-thyro globulin antibodies, Thus, even when the donor is in a subclinical sta te, autoimmune thyroiditis may be transferred from donors to recipient s by BMT.