HEMOLYTIC-UREMIC SYNDROME FOLLOWING AUTOLOGOUS PERIPHERAL-BLOOD STEM-CELL TRANSPLANTATION IN A PATIENT WITH MALIGNANT-LYMPHOMA

Hemolytic uremic syndrome (HUS) has been reported in patients receivin g bone marrow transplantation. However, only a few cases of HUS follow ing autologous peripheral blood stem cell transplantation (PBSCT) have been reported. We present a case of HUS developing after autologous P BSCT in a 40-year-old man with non-Hodgkin's lymphoma, It appears that the chemotherapeutic agents administered during the conditioning regi men for PBSCT may have played an important role in the development of HUS in our patient. In the present case, the combination therapy of vi ncristine, methylprednisolone, and ticlopidine hydrochloride was effec tive.