REVERSIBLE BRAIN MRI CHANGES IN ACYCLOVIR NEUROTOXICITY

This case report shows reversible brain MRI changes probably associate d with acyclovir toxicity. So far, neuroimaging in acyclovir toxicity had been negative or uninformative, A 12-year-old girl developed focal secondary generalizing epileptic fits following 4 weeks of prophylact ic administration of acyclovir (3 x 10 mg/kg body weight/day i.v.) on day +22 after allogeneic peripheral blood stem cell transplantation fo r CML, Infective causes were excluded, Brain MRI demonstrated multiple gadolinium-enhancing areas with impairment of the blood-brain barrier in cortical and subcortical regions, Clinical symptoms and neuroimagi ng pathology resolved completely within 9 days of acyclovir withdrawal .