DETECTION OF HEPATITIS-G VIRUS FROM SERUM AND LIVER OF A PATIENT WITHLONG-TERM LIVER DYSFUNCTION AFTER AUTOLOGOUS BONE-MARROW TRANSPLANTATION

Long-term effects after blood or bone marrow transplantation (BMT) are emerging as an important issue, as more patients are included in BMT programmes and as this procedure becomes more successful. Long-term li ver dysfunction, mainly due to chronic graft-versushost disease or hep atitis C virus infection, is a well-known complication. Nevertheless, the diagnosis of liver disease in this patient group is sometimes diff icult and, despite adequate studies, it may remain undetected. A novel hepatitis-associated virus, hepatitis G virus (HGV), has recently bee n identified, The virus belongs to the Flaviviridae family and is know n to be parenterally transmitted, although there is no clear evidence to implicate this agent in causing acute or chronic hepatitis, We repo rt a patient who developed mild, but persistent, abnormalities in tran saminases for 2 years after an autologous BMT, HGV RNA was detected in both serum and liver, HGV RNA persisted in serum for at least 8 month s. No other known hepatitis virus was found, This report provides the first direct evidence of a patient with long-term liver abnormalities after a BMT in whom the only known hepatitis virus isolated was the HG V.