ABSENCE OF ENTEROVIRAL AND CARDIOVIRAL RNA IN MULTIPLE-SCLEROSIS BRAIN-TISSUE

Citation
Rb. Dessau et al., ABSENCE OF ENTEROVIRAL AND CARDIOVIRAL RNA IN MULTIPLE-SCLEROSIS BRAIN-TISSUE, Acta neurologica Scandinavica, 95(5), 1997, pp. 284-286
Citations number
11
Categorie Soggetti
Clinical Neurology
ISSN journal
00016314
Volume
95
Issue
5
Year of publication
1997
Pages
284 - 286
Database
ISI
SICI code
0001-6314(1997)95:5<284:AOEACR>2.0.ZU;2-N
Abstract
Objectives - Epidemiological evidence suggests that an infectious agen t may be involved in the pathogenesis of multiple sclerosis (MS). Pico rnaviruses are possible candidates for an etiological agent, because o f their neurotropic properties and ability to cause chronic infections . Materials and methods - Autopsy brain tissue from 25 patients with c linically definite MS and 33 control patients without inflammatory neu rological disease was tested with reverse transcription PCR specific f or enteroviruses and cardioviruses. Results - All specimens were found negative. Conclusion - These results do not support the theory of a p ersisting entero- or cardioviral infection as the cause of MS as we fo und no evidence of the presence of entero- or cardioviral genomes in t he brains from MS patients.