Ef. Marshall et al., STRIATAL DOPAMINERGIC LOSS WITHOUT PARKINSONISM IN A CASE OF CORTICOBASAL DEGENERATION, Acta neurologica Scandinavica, 95(5), 1997, pp. 287-292
Neurochemical analyses of post-mortem brain from cases of corticobasal
degeneration are extremely rare although nearly 100 cases have been r
eported in the literature. We detail findings of neurotransmitter dera
ngement in the basal ganglia of a case of neuropathologically confirme
d corticobasal degeneration, who presented with dementia. The implicat
ions of severe neuronal loss in the substantia nigra and extremely low
levels of dopamine and its metabolites in the striatum are considered
in relation to the absence of an intrinsic extrapyramidal syndrome.