DOMINO LIVER-TRANSPLANTATION FOR FAMILIAL AMYLOID POLYNEUROPATHY

Familial amyloid polyneuropathy is an autosomal dominant disorder in w hich the liver produces a variant prealbumin that is deposited along n erves, leading to a progressive and fatal polyneuropathy that begins i n the third decade of life. Liver transplantation has been the only su ccessful treatment to date. Apart from the production of the variant p rotein, there are no other abnormalities in these amyloid livers. We d escribe two cases in which, at the time of transplantation, the amyloi d livers were subsequently used for transplantation in another patient , and we discuss the implications. Copyright (C) 1998 by the American Association for the Study of Liver Diseases.