Since the beginning of human space flight, NASA has been placing human
s in extreme and remote environments. There are many challenges in mai
ntaining humans in outer space, including the provision of life-suppor
t systems, radiation shielding, and countermeasures for minimizing the
effect of microgravity. Because astronauts are selected for their hea
lth, among other factors, disease and illness are minimized. However,
it is still of great importance to have appropriate medical care syste
ms in place to address illness and injury should they occur. With the
exception of the Apollo program, exploration of space has been limited
to missions that are within several hundred miles of the surface of t
he Earth. At the dawn of the 21st century and the new millennium, huma
n exploration will be focused on operation of the International Space
Station (ISS) and preparation for human missions to Mars. These missio
ns will present inherent risks to human health, and, therefore, approp
riate plans must be established to address these challenges and risks.
Crews of long-duration missions must become more independent from gro
und controllers. New systems, protocols, and procedures are currently
being perfected. Application of emerging technologies in information s
ystems and telecommunications will be critical to inflight medical car
e. Application of these technologies through telemedicine will provide
crew members access to information, noninvasive procedures for assess
ing health status, and guidance through the integration of sensors, ho
lography, decision-support systems, and virtual environments. These te
chnologies will also serve as a basis to enhance training and medical
education. The design of medical care for space flight should lead to
a redesign of the practice of medicine on Earth.