MAGNESIUM MEERWEIN-PONNDORF-VERLEY-OPPENAUER REACTION - THE ORIGIN OFAN IMPURITY IN PDA-641 BATCHES

Authors
WILK BK HELOM JL COUGHLIN CW
Citation
Bk. Wilk et al., MAGNESIUM MEERWEIN-PONNDORF-VERLEY-OPPENAUER REACTION - THE ORIGIN OFAN IMPURITY IN PDA-641 BATCHES, Organic process research & development, 2(6), 1998, pp. 407-411
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Organic process research & development → ACNP
ISSN journal
10836160
Volume
2
Issue
6
Year of publication
1998
Pages
407 - 411
Database
ISI
SICI code
1083-6160(1998)2:6<407:MMR-TO>2.0.ZU;2-2
Abstract
An impurity in the initial scale-up batch of PDA-641 was identified an d the pathway of its formation was established. The precursor of the i mpurity was formed by magnesium Meerwein-Ponndorf-Verley-Oppenauer rea ction during the Grignard addition step. As a result of the investigat ion, the level of the impurity could be reduced 6-fold in the subseque nt batch.