PROCESS FOR THE CAPTURE AND REUSE OF THE 4,4'-DIMETHOXYTRIPHENYLMETHYL GROUP DURING MANUFACTURING OF OLIGONUCLEOTIDES

Authors
GUO ZQ PFUNDHELLER HM SANGHVI YS
Citation
Zq. Guo et al., PROCESS FOR THE CAPTURE AND REUSE OF THE 4,4'-DIMETHOXYTRIPHENYLMETHYL GROUP DURING MANUFACTURING OF OLIGONUCLEOTIDES, Organic process research & development, 2(6), 1998, pp. 415-417
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Organic process research & development → ACNP
ISSN journal
10836160
Volume
2
Issue
6
Year of publication
1998
Pages
415 - 417
Database
ISI
SICI code
1083-6160(1998)2:6<415:PFTCAR>2.0.ZU;2-P
Abstract
In a standard amidite coupling-based automated oligonucleotide synthes is campaign, the 4,4'-dimethoxytriphenylmethyl (DMT) protecting group is discarded as waste along with large amounts of dichloromethane, Her ein, we report a straightforward and simple process for complete captu re and recovery of the DMT group and dichloromethane, rendering the ol igonucleotide manufacturing process safer and more economical.