NATURAL-KILLER AND T-CELLS OF INNATE AND ADAPTIVE IMMUNITY - LYMPHOIDCOMPARTMENTS WITH DIFFERENT REQUIREMENTS FOR COMMON GAMMA-CHAIN-DEPENDENT CYTOKINES

Citation
Jp. Disanto et al., NATURAL-KILLER AND T-CELLS OF INNATE AND ADAPTIVE IMMUNITY - LYMPHOIDCOMPARTMENTS WITH DIFFERENT REQUIREMENTS FOR COMMON GAMMA-CHAIN-DEPENDENT CYTOKINES, Immunological reviews, 165, 1998, pp. 29-38
Citations number
85
Categorie Soggetti
Immunology
Journal title
ISSN journal
01052896
Volume
165
Year of publication
1998
Pages
29 - 38
Database
ISI
SICI code
0105-2896(1998)165:<29:NATOIA>2.0.ZU;2-E
Abstract
A group of cytokines, including interleukin-2, -4, -7, -9 and -15, are related through the usage of a shared receptor subunit, the common cy tokine receptor gamma chain, gamma(c). gamma(c)-dependent cytokines cr itically affect the development and maintenance of the lymphoid system . This review will highlight our current knowledge on the gamma(c)-dep endent cytokine network and on the non-redundant roles that these cyto kines play in the development and homeostasis of T and natural killer cells involved in innate and adaptive immunity.