DIASTEREOSELECTIVE ALKYLATION OF A NEWLY DESIGNED BISLACTIM ETHER TOWARDS THE ASYMMETRIC-SYNTHESIS OF ALPHA-ALKYLATED SERINES

Authors
SANO S TAKEBAYASHI M MIWA T ISHII T NAGAO Y
Citation
S. Sano et al., DIASTEREOSELECTIVE ALKYLATION OF A NEWLY DESIGNED BISLACTIM ETHER TOWARDS THE ASYMMETRIC-SYNTHESIS OF ALPHA-ALKYLATED SERINES, Tetrahedron : asymmetry, 9(20), 1998, pp. 3611-3614
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
9
Issue
20
Year of publication
1998
Pages
3611 - 3614
Database
ISI
SICI code
0957-4166(1998)9:20<3611:DAOAND>2.0.ZU;2-Q
Abstract
Diastereoselective alkylation of ethyl hoxy-2,5-dihydro-5-isopropyl-2- pyrazinecarboxylate (5S)-3 with alkyl halides was investigated by usin g NaH and n-BuLi. These alkylated products (2R,5S)-4b-d were converted to the corresponding alpha-alkylated serines (S)-6b-d. (C) 1998 Elsev ier Science Ltd. All rights reserved.