The main goal of the Frequency Assignment Problem in mobile radio netw
orks consists of assigning a limited number of frequencies to each rad
io cell in a cellular network while minimizing electromagnetic interfe
rence due to the reuse of frequencies. This problem, known to be NP-ha
rd, is of great importance in practice since better solutions will all
ow a telecommunications operator to manage larger cellular networks. T
his paper presents a new Tabu Search algorithm for this application. T
he algorithm is tested on realistic and large problem instances and co
mpared with other methods based on simulated annealing, constraint pro
gramming and graph coloring algorithms. Empirical evidence shows that
the Tabu algorithm is very competitive by giving the best solutions to
the tested instances.