COMPLEXATION OF COPPER-ION AND NUCLEOTIDES AND CATALYTIC HYDROLYSIS OF ATP BY AN OCTAAZA MACROCYCLIC LIGAND ,9,17,20,23,29,30-OCTAAZATRICYCLO[23,3,1,1(11,15)] TRIACONTA-1(29),11,13,15,25,27-HEXAENE

The complexation of copper(II) ion and nucleotides by an octaaza macro cyclic ligand 3,6,9,17,20,23,29,30-octaazatricyclo ,1,1(11,15)]trracon ta-1(29),11,13,15,25,27-hexaene (BPBD) has been studied by potentiomet ric titration. Catalytic hydrolysis of ATP promoted by protonated BPBD has been investigated and the influence of pH on rate enhancements ha ve been determined by HPLC. In addition, the crystal structure of a di nuclear Cu(II) complex [BPBDCu2](ClO4)(4). 4DMF (1) and the preliminar y structure of a binary complex HxBPBD-Tp (2) are reported. Complex 1 crystallizes in the triclinic system, space group P (1) over bar, with a = 11.908(8), b = 12.851(1), c = 9.209(7) Angstrom, alpha = 107.20(6 ), beta = 101.85(6), gamma = 68.84(6)degrees, and Z = 2. Each copper(I I) ion is coordinated by one pyridine nitrogen and three amino nitroge ns, forming a square planar geometry. (C) 1998 Elsevier Science B.V. A ll rights reserved.