METHIONINE INDUCES SEXUAL DEVELOPMENT IN THE FISSION YEAST SCHIZOSACCHAROMYCES-POMBE VIA AN STE11-DEPENDENT SIGNALING PATHWAY

Authors
SCHWEINGRUBER AM HILTI N EDENHARTER E SCHWEINGRUBER ME
Citation
Am. Schweingruber et al., METHIONINE INDUCES SEXUAL DEVELOPMENT IN THE FISSION YEAST SCHIZOSACCHAROMYCES-POMBE VIA AN STE11-DEPENDENT SIGNALING PATHWAY, Journal of bacteriology (Print), 180(23), 1998, pp. 6338-6341
Citations number
18
Categorie Soggetti
Microbiology
Journal title
Journal of bacteriology (Print) → ACNP
ISSN journal
00219193
Volume
180
Issue
23
Year of publication
1998
Pages
6338 - 6341
Database
ISI
SICI code
0021-9193(1998)180:23<6338:MISDIT>2.0.ZU;2-T
Abstract
Methionine added to minimal medium overcomes the repressing effects of ammonium and cyclic AMP (cAMP) an sexual development and efficiently induces mating and sporulation in homothallic strains of Schizosacchar omyces pombe. In heterothallic strains it induces G(1) arrest when cel ls enter stationary phase. We show that methionine reduces the intrace llular cAMP pool and induces the expression of at least two cAMP-repre ssible genes, including fbp1 and ste11, The easiest interpretation of the results is that methionine induces sexual development via a cAMP-d ependent ste11 signalling pathway.