Chronic venous insufficiency represents a sizable burden to the health
care system owing to its significant morbidity. Current medical and s
urgical therapies are often ineffective in obtaining excellent long-te
rm control of this disease. This has prompted the development of a syn
thetic vein valve for the treatment of chronic venous insufficiency. E
leven dogs underwent the implantation of twelve valves into the femora
l veins. Initial studies showed the valves to be competent and patent.
However, over a two-year period, dense ingrowth of intimal hyperplasi
a rendered the valves functionless.