CELL-CYCLE ARREST FOLLOWING EXPOSURE OF EBV-IMMORTALIZED B-CELLS TO GAMMA-IRRADIATION CORRELATES WITH INHIBITION OF CDK2 ACTIVITY

Authors
CANNELL EJ FARRELL PJ SINCLAIR AJ
Citation
Ej. Cannell et al., CELL-CYCLE ARREST FOLLOWING EXPOSURE OF EBV-IMMORTALIZED B-CELLS TO GAMMA-IRRADIATION CORRELATES WITH INHIBITION OF CDK2 ACTIVITY, FEBS letters, 439(3), 1998, pp. 297-301
Citations number
23
Categorie Soggetti
Biology,"Cell Biology",Biophysics
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
439
Issue
3
Year of publication
1998
Pages
297 - 301
Database
ISI
SICI code
0014-5793(1998)439:3<297:CAFEOE>2.0.ZU;2-2
Abstract
The exposure of Epstein-Barr virus immortalised B cells (LCLs) to the genotoxic effects of gamma irradiation causes a decreased proliferatio n of the cells. The early events in this process have been investigate d here. The induction of p53 expression correlates with a cell cycle a rrest in the G1 and G2/M phases of the cell cycle within 24 h of expos ure, The molecular mechanism governing the decreased proliferation app ears to involve the induction of the cyclin dependent kinase (cdk) inh ibitor p21(CIP1) and its functional association with cdk2, (C) 1998 Fe deration of European Biochemical Societies.