SCLERODERMATOUS GRAFT-VERSUS-HOST DISEASE AFTER DONOR LEUKOCYTE INFUSION

Leucocyte infusion from the marrow donor is a new therapeutic option t o avoid repeated bone marrow transplants in patients with recurrent le ukaemia. The treatment is based on the fact that alloreactive donor im mune cells may recognize and eliminate residual leukaemia cells. This phenomenon has been called graft-versus-leukaemia. We describe a patie nt who received donor leucocyte infusion for a relapsed chronic myeloi d leukaemia after his second bone marrow transplant and developed scle rodermatous graft-versus-host disease.