CHANGES IN EXTRACELLULAR BRAIN ASCORBATE IN RAT STRIATUM IN RESPONSE TO ADMINISTRATION OF NONVOLATILE ANESTHETIC AGENTS

Authors
MIELE M FILLENZ M
Citation
M. Miele et M. Fillenz, CHANGES IN EXTRACELLULAR BRAIN ASCORBATE IN RAT STRIATUM IN RESPONSE TO ADMINISTRATION OF NONVOLATILE ANESTHETIC AGENTS, British Journal of Anaesthesia, 78(5), 1997, pp. 588-590
Citations number
6
Categorie Soggetti
Anesthesiology
Journal title
British Journal of Anaesthesia → ACNP
ISSN journal
00070912
Volume
78
Issue
5
Year of publication
1997
Pages
588 - 590
Database
ISI
SICI code
0007-0912(1997)78:5<588:CIEBAI>2.0.ZU;2-K
Abstract
We used constant potential in vivo voltammetry to measure changes in s triatal ascorbate in the rat in response to i.p. administration of sev eral nonvolatile anaesthetics. Propofol and pentobarbitone, which enha nce GABA-mediated neuronal inhibitions, decreased ascorbate current to 27.0 (SEM 7.4) % and 46 (6) % of control, respectively. Chloral hydra te, diazepam alone or with ketamine, and fentanyl-fluanisone with mida zolam produced no changes in ascorbate current.