ROD-SPARING PARANEOPLASTIC RETINOPATHY, OPSOCLONUS, AND PERIPHERAL NEUROPATHY DUE TO SMALL-CELL LUNG-CARCINOMA

A 45-year-old female developed a sensorimotor polyneuropathy. Later, v isual acuity, color vision, and day vision deteriorated progressively, Macular pigment epithelial mottling led to an electroretinogram, whic h revealed a relatively rod-sparing photoreceptor degeneration, A para neoplastic syndrome was suspected and confirmed by bronchoscopy, discl osing a small cell lung carcinoma, and by positive CAR antibody titers , Subsequently, opsoclonus appeared, Although frequently patients with neurological paraneoplastic syndromes may have mixtures of the differ ent syndromes, this is, to our knowledge, the first report of an assoc iation of CAR with paraneoplastic opsoclonus and peripheral neuropathy , We confirm a previous report by Cogan that paraneoplastic retinopath y may spare the rods and clinically present with central scotoma, dysc hromatopsia, and hemeralopia.