DIBENZO[1,6]NAPHTHYRIDINDIONES AS MODIFIED QUINOLONE ANTIBACTERIALS

Authors
CECCHETTI V FRAVOLINI A SABATINI S TABARRINI O XIN T
Citation
V. Cecchetti et al., DIBENZO[1,6]NAPHTHYRIDINDIONES AS MODIFIED QUINOLONE ANTIBACTERIALS, European journal of medicinal chemistry, 33(11), 1998, pp. 899-903
Citations number
18
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
33
Issue
11
Year of publication
1998
Pages
899 - 903
Database
ISI
SICI code
0223-5234(1998)33:11<899:DAMQA>2.0.ZU;2-2
Abstract
A series of dibenzo[1,6]naphthyridindiones, synthesized as modified qu inolones, in which the usual carboxylic group was replaced by a hetero cyclic amide function, was evaluated for antibacterial activity. None of the target compounds showed any significant antibacterial activity. Semiempirical molecular orbital AM1 calculations allowed us to hypoth esize that the lack of activity could depend on amide tautomeric equil ibrium. (C) Elsevier, Paris.