STEREOSELECTIVE SYNTHESIS OF ALPHA-L-BICARBOCYCLIC NUCLEOSIDES AS POTENTIAL ANTIVIRAL DRUGS

Authors
DEMAISON C HOURIOUX C ROINGEARD P AGROFOGLIO LA
Citation
C. Demaison et al., STEREOSELECTIVE SYNTHESIS OF ALPHA-L-BICARBOCYCLIC NUCLEOSIDES AS POTENTIAL ANTIVIRAL DRUGS, Tetrahedron letters, 39(50), 1998, pp. 9175-9178
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
50
Year of publication
1998
Pages
9175 - 9178
Database
ISI
SICI code
0040-4039(1998)39:50<9175:SSOANA>2.0.ZU;2-5
Abstract
Synthesis of hitherto unknown carbocyclic alpha-L-isomeric bicyclo[3.1 .0]hexyl nucleosides (8-11) is described. The key intermediate 7 was s ynthesized in seven steps from the known chiral compound 1 through a s tereoselective cyclopropanation under Furukawa conditions. Compounds 8 -11 were evaluated as anti-HBV agents in HepG2T14 cells. (C) 1998 Publ ished by Elsevier Science Ltd. All rights reserved.