SYNTHESIS OF SUBSTITUTED (D)-PHENYLALANINE DERIVATIVES BY REGIOSELECTIVE REDUCTION OF ENANTIOMERICALLY PURE CIS-2,3-DISUBSTITUTED AZIRIDINES

Authors
CHANG JW BAE JH SHIN SH PARK CS CHOI D LEE WK
Citation
Jw. Chang et al., SYNTHESIS OF SUBSTITUTED (D)-PHENYLALANINE DERIVATIVES BY REGIOSELECTIVE REDUCTION OF ENANTIOMERICALLY PURE CIS-2,3-DISUBSTITUTED AZIRIDINES, Tetrahedron letters, 39(50), 1998, pp. 9193-9196
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
50
Year of publication
1998
Pages
9193 - 9196
Database
ISI
SICI code
0040-4039(1998)39:50<9193:SOS(DB>2.0.ZU;2-C
Abstract
Various (R)-(+)-(alpha-methylbenzyl)-(2R,3R)-disubstituted aziridines were prepared by intramolecular cyclization. The regioselective reduct ion of the ring C(3)-N bond in the presence of (Boc)(2)O by catalytic hydrogenation with atmospheric pressure of hydrogen provides (D)-pheny lalaninol analogues in good yields. (C) 1998 Elsevier Science Ltd. All rights reserved.