SYNTHESIS OF 2-AMINO-2'-DIPHENYLPHOSPHINO-1,1'-BINAPHTHYL (MAP) AND ITS ACCELERATING EFFECT ON THE PD(0)-CATALYZED N-ARYLATION

Authors
VYSKOCIL S SMRCINA M KOCOVSKY P
Citation
S. Vyskocil et al., SYNTHESIS OF 2-AMINO-2'-DIPHENYLPHOSPHINO-1,1'-BINAPHTHYL (MAP) AND ITS ACCELERATING EFFECT ON THE PD(0)-CATALYZED N-ARYLATION, Tetrahedron letters, 39(50), 1998, pp. 9289-9292
Citations number
31
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
50
Year of publication
1998
Pages
9289 - 9292
Database
ISI
SICI code
0040-4039(1998)39:50<9289:SO2(AI>2.0.ZU;2-G
Abstract
The title compound 3, synthesized in four steps from NOBIN (1), has be en found to exhibit a dramatic accelerating effect on the Pd(0)-cataly zed Hartwig-Buchwald N-phenylation of amino alcohol 1 and diamine 8 wi th PhBr. Partial kinetic resolution was observed for the phenylation o f (+/-)-1 or (+)-8 in the presence of(S)-BINAP. (C) 1998 Elsevier Scie nce Ltd. All rights reserved.