TOPOSTATIN, A NOVEL INHIBITOR OF TOPOISOMERASE-I AND TOPOISOMERASE-IIPRODUCED BY THERMOMONOSPORA-ALBA STRAIN-NO-1520 - II - PHYSICOCHEMICAL PROPERTIES AND STRUCTURE ELUCIDATION

Authors
SUZUKI K YAHARA S KIDO Y NAGAO K HATANO Y UYEDA M
Citation
K. Suzuki et al., TOPOSTATIN, A NOVEL INHIBITOR OF TOPOISOMERASE-I AND TOPOISOMERASE-IIPRODUCED BY THERMOMONOSPORA-ALBA STRAIN-NO-1520 - II - PHYSICOCHEMICAL PROPERTIES AND STRUCTURE ELUCIDATION, Journal of antibiotics, 51(11), 1998, pp. 999-1003
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology,"Biothechnology & Applied Migrobiology",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
51
Issue
11
Year of publication
1998
Pages
999 - 1003
Database
ISI
SICI code
0021-8820(1998)51:11<999:TANIOT>2.0.ZU;2-6
Abstract
Topostatin is a new topoisomerase inhibitor isolated from the culture filtrate of Thermomonospora alba strain No. 1520. The inhibitor inhibi ts topoisomerases I and II, and it has neither ability to stabilize th e cleavable complex nor ability to intercalate into DNA strands. The m olecular formula of topostatin was determined as C36H58N4O11S based on the FAB-MS analyses, and the structure was elucidated to be a novel 1 4-membered ring containing peptide and terpenoid by various NMR spectr oscopies.