IMMUNOLOGICAL VARIABLES IN NORMAL-PREGNANCY AND SPONTANEOUS-ABORTION

Objective-The aim of the study was to establish if pregnancy belongs t o pathological situations, if it changes SIL-2R, sCD4 and sCD8 levels, and to verify if these levels have a prognostic value in the evaluati on of pregnancy. Patients and Methods-Thirty pregnant women in the fir st trimester of pregnancy were studied. Ten of them had a normal evolu tion of pregnancy, ten had a threatened abortion with a bad outcome, a nd ten had an ectopic pregnancy. We determined SIL-2R, sCD4, and sCD8 levels in the serum and in the amniotic fluid in 10 pregnant women in their second trimester, and in 10 healthy women without pregnancy (con trol group). Results-We found that (a) 50% of the pregnant women in th eir first trimester had abnormal SIL-2R values, and 90% had abnormal s CD8 values; (b) 9/10 women with threatened abortion and bad outcome ha d abnormal SIL-2R values; (c) SIL-2R levels were significantly higher in the amniotic fluid than in the serum (P < .001). Conclusion-Our res ults sustain the opinion that pregnancy must be included among those s ituations that increase SIL-2R, sCD4, and sCD8 levels. SIL-2R levels g reater than 1,300 U/mL carried a bad prognosis in the evolution of pre gnancy.