THERAPY OF A XENOGRAFTED HUMAN COLONIC-CARCINOMA USING CISPLATIN OR DOXORUBICIN ENCAPSULATED IN LONG-CIRCULATING PEGYLATED STEALTH LIPOSOMES

We compared the therapeutic effects of low doses of cisplatin and doxo rubicin hydrochloride encapsulated in long-circulating liposomes compo sed of cholesterol/hydrogenated soy phosphatidylcholine-polyethylene g lycol-distearoyl phosphatidyl ethanolamine. The encapsulation of cispl atin and doxorubicin in these liposomes made ineffectively low doses o f the free drugs able to inhibit the growth of and affect cures of a h uman colonic carcinoma growing in nude mice, Liposome-encapsulated cis platin had minor systemic toxic side effects indicated by an average 9 % weight loss which was recovered 3-4 weeks after the last treatment. Toxicity was not observed in mice treated with liposome-encapsulated d oxorubicin. (C) 1999 Wiley-Liss, Inc.