J. Vaage et al., THERAPY OF A XENOGRAFTED HUMAN COLONIC-CARCINOMA USING CISPLATIN OR DOXORUBICIN ENCAPSULATED IN LONG-CIRCULATING PEGYLATED STEALTH LIPOSOMES, International journal of cancer, 80(1), 1999, pp. 134-137
We compared the therapeutic effects of low doses of cisplatin and doxo
rubicin hydrochloride encapsulated in long-circulating liposomes compo
sed of cholesterol/hydrogenated soy phosphatidylcholine-polyethylene g
lycol-distearoyl phosphatidyl ethanolamine. The encapsulation of cispl
atin and doxorubicin in these liposomes made ineffectively low doses o
f the free drugs able to inhibit the growth of and affect cures of a h
uman colonic carcinoma growing in nude mice, Liposome-encapsulated cis
platin had minor systemic toxic side effects indicated by an average 9
% weight loss which was recovered 3-4 weeks after the last treatment.
Toxicity was not observed in mice treated with liposome-encapsulated d
oxorubicin. (C) 1999 Wiley-Liss, Inc.