A SYNTHETIC APPROACH TO CARBOCYCLIC SINEFUNGIN

Authors
DASILVA AD MARIA EJ BLANCHARD P FOURREY JL ROBERTGERO M
Citation
Ad. Dasilva et al., A SYNTHETIC APPROACH TO CARBOCYCLIC SINEFUNGIN, Nucleosides & nucleotides, 17(12), 1998, pp. 2175-2187
Citations number
35
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
17
Issue
12
Year of publication
1998
Pages
2175 - 2187
Database
ISI
SICI code
0732-8311(1998)17:12<2175:ASATCS>2.0.ZU;2-B
Abstract
An approach to an asymmetric synthesis of carbocyclic sinefungin (cSF) 2 is proposed. The sequence, which uses an original radical based che mistry for C-C bond formation, led to the immediate precursor 18 of th e protected desired compound. While the overall yield is modest, it is noticeable that only a limited number of steps are needed to obtain t he target compound.