SOME ASPECTS ON ACYCLONUCLEOSIDE SYNTHESIS

Authors
UBASAWA M TAKASHIMA H SEKIYA K
Citation
M. Ubasawa et al., SOME ASPECTS ON ACYCLONUCLEOSIDE SYNTHESIS, Nucleosides & nucleotides, 17(12), 1998, pp. 2241-2247
Citations number
11
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
17
Issue
12
Year of publication
1998
Pages
2241 - 2247
Database
ISI
SICI code
0732-8311(1998)17:12<2241:SAOAS>2.0.ZU;2-8
Abstract
An acyclonucleoside synthesis was investigated on the regioselective i ntroduction of an acyclochain. We found that iodotrimethylsilane catal yzed the reaction of acyclochain introduction as well as its migration from S-2 to N-1 of 2-thiothymine and from N-7 to N-9 position of guan ine. By taking the findings into account, several acyclonucleosides we re synthesized in a simple one-pot procedure.