3'-DEOXY-3'-C-TRIFLUOROMETHYL NUCLEOSIDES - SYNTHESIS AND ANTIVIRAL EVALUATION

Authors
LAVAIRE S PLANTIERROYON R PORTELLA C DEMONTE M KIRN A AUBERTIN AM
Citation
S. Lavaire et al., 3'-DEOXY-3'-C-TRIFLUOROMETHYL NUCLEOSIDES - SYNTHESIS AND ANTIVIRAL EVALUATION, Nucleosides & nucleotides, 17(12), 1998, pp. 2267-2280
Citations number
28
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
17
Issue
12
Year of publication
1998
Pages
2267 - 2280
Database
ISI
SICI code
0732-8311(1998)17:12<2267:3N-SAA>2.0.ZU;2-T
Abstract
2',3'-Dideoxy-3'-C-trifluoromethylthymidine 9a and -uridine 9b and 3'- C-trifluoromethyl-d(4)T 11 were prepared in a few steps from 3'-deoxy- 3'-C-trifluoromethyl-D-ribose, which synthesis was recently reported. The biological assessment of these nucleoside analogues did not reveal interesting antiviral properties against HIV-1, HSV-1, CMV, Vaccine, and Cox B4.