EXTENSION OF THE APPLICABILITY OF DELTA-J-VALUES FOR THE CONFIGURATIONAL ASSIGNMENT OF DIASTEREOMERIC PHOSPHATE-MODIFIED DIDEOXYNUCLEOTIDES

Authors
MACHYTKA D GACSBAITZ E TEGYEY Z
Citation
D. Machytka et al., EXTENSION OF THE APPLICABILITY OF DELTA-J-VALUES FOR THE CONFIGURATIONAL ASSIGNMENT OF DIASTEREOMERIC PHOSPHATE-MODIFIED DIDEOXYNUCLEOTIDES, Nucleosides & nucleotides, 17(12), 1998, pp. 2311-2322
Citations number
10
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
17
Issue
12
Year of publication
1998
Pages
2311 - 2322
Database
ISI
SICI code
0732-8311(1998)17:12<2311:EOTAOD>2.0.ZU;2-#
Abstract
The stereochemical assignment of dinucleoside-S-p-nitrobenzyl-phosphor othioates by NMR spectroscopy is reported. It was found that the metho d based on the difference of the vicinal phosphorus-carbon coupling co nstants (Delta J = (3)J(C4',P) - (3)J(C2',P)) can widely be applied fo r the determination of the configuration at the pohosphorus atom in ph osphate-modified dideoxynucleotides.