SYNTHESIS OF PEPTIDINOL ADENYLATES

Peptidinol adenylates were assembled by condensing the carboxyl group of N-blocked peptides with the alkylamino group of leucinol 5' adenosi ne phosphodiester. The latter was prepared as protected precursor from adenosine and leucinol by phosphite chemistry. The title compounds, w hich mimic aminoacyl adenylates, are designed to penetrate microorgani sms via peptide permeases and to interfere with genetic translation.