DESIGN, SYNTHESIS AND ANTIVIRAL ACTIVITY OF ALPHA-L-ARABINOFURANOSYL DERIVATIVES OF 2-SUBSTITUTED-5,6-DICHLOROBENZIMIDAZOLES

A number of ichloro-1-(alpha-L-arabinofuranosyl)benzimidazoles have be en prepared by condensation of 2-bromo-5,6-dichlorobenzimidazole or 2, 5,6-trichlorobenzimidazole with tetra-O-acetyl-L-arabinofuranose. 2-Al kylamino derivatives were prepared by a substitution of the 2-chloro g roup with the appropriate amines. All target compounds were evaluated for activity against HCMV and HSV-1. The 2-chloro and 2-bromo derivati ves showed moderate activity against HCMV at non-cytotoxic concentrati ons.