PATIENTS OUTCOME AFTER TREATMENT OF AN OVARIAN-CANCER BY INTRAPERITONEAL IMMUNOCHEMOTHERAPY

Objective : The aim of this study is to show that ip chemotherapy impr oves the evolution of the patients with an ovarian cancer, as the risk of a small number of complications due to this route of administratio n Methods : 85 patients (I I stage Ic, 4 IIc and 70 stage III) were tr eated from 1980 to 1993 (median of follow up > 77 months) by a cisplat in based immunochemotherapy administered intraperitoneally, by a needl e. Results : Median overall survival exceeds, 72 months (60 months for stage ill). Cut of 41 relapses II took place after 48 months of follo w up. Delayed general complications consisted of 2 chronic nephotoxici ties due to CDDP and one leukemia. Local complications are dominated b y serous adherences (5 cases of plastic peritonitis). Secondary cytore ductions turned out to be beneficial in this series in spite of relaps e diagnosis of them being carried out to late. Conclusion : Classic im agery remains disappointing for the exploration of the pelvic abdomina l region, Paclitaxel by ip way seems very promising, which should laun ch once again interest in secondary debulking surgery.