Cocaine use among methadone patients has been related to higher preval
ence of HIV risk behaviors. HIV risk behaviors for cocaine-using patie
nts in methadone treatment (N = 207) were examined for two time period
s, the current month in-treatment and the month previous to treatment
admission. All needle-related and sexually-related risk behaviors (exc
ept for needle hygiene) significantly and substantially declined over
the average two year time interval. Several variables were associated
with needle and sexual risks in multivariate regression analyses. Drop
ping apparent opiate use underreporters from the analyses did not alte
r the results. From a harm reduction perspective, high priority should
be given to retaining cocaine-using patients in methadone maintenance
, intensifying in-program services for those with antisocial personali
ty, bipolar disorder or alcoholism, as well as increasing access to ne
edle exchanges and free condoms.