AN EFFICIENT SYNTHESIS OF ((9-FLUORENYL-METHOXYCARBONYL)AMINO)METHYL)BENZOIC ACID

Authors
SUN JH DANEKER WF
Citation
Jh. Sun et Wf. Daneker, AN EFFICIENT SYNTHESIS OF ((9-FLUORENYL-METHOXYCARBONYL)AMINO)METHYL)BENZOIC ACID, Synthetic communications, 28(24), 1998, pp. 4525-4530
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
28
Issue
24
Year of publication
1998
Pages
4525 - 4530
Database
ISI
SICI code
0039-7911(1998)28:24<4525:AESO(>2.0.ZU;2-Z
Abstract
An efficient, two-step syntesis of the title compound 3 in 61% overall yield is presented. The synthesis involves hydrazine removal of the N -phthalimide protecting group of alpha-phthalimido-o-toluic acid (6), followed by N-Fmoc formation with (9-fluorenylmethyl)succinimidyl carb onate.