SYNTHESIS OF -DIHYDROBENZO[4,5]CYCLOHEPT[1,2-B]INDOL-12(5H)-ONE AND RELATED-COMPOUNDS

Authors
JOSEPH B CORNEC O MEROUR JY SOLANS X FONTBARDIA M
Citation
B. Joseph et al., SYNTHESIS OF -DIHYDROBENZO[4,5]CYCLOHEPT[1,2-B]INDOL-12(5H)-ONE AND RELATED-COMPOUNDS, Journal of heterocyclic chemistry, 34(2), 1997, pp. 525-531
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
34
Issue
2
Year of publication
1997
Pages
525 - 531
Database
ISI
SICI code
0022-152X(1997)34:2<525:SO-AR>2.0.ZU;2-B
Abstract
The synthetic routes of -dihydrobenzo[4,5]cyclohept[1,2-b]indol-12(5H) -one 5 from either 1-methyl or 1-sulfonylindole-2-carboxaldehyde 1 or ethyl 1,2-dimethylindole-3-carboxylate 6 are reported. The structure o f the ketone 5a was confirmed by X-ray crystallography. Several indole derivatives have been prepared with potential antitumor activity.