INTERFERON-BETA PLUS INOSIPLEX IN THE TREATMENT OF SUBACUTE SCLEROSING PANENCEPHALITIS

Citation
B. Anlar et al., INTERFERON-BETA PLUS INOSIPLEX IN THE TREATMENT OF SUBACUTE SCLEROSING PANENCEPHALITIS, Journal of child neurology, 13(11), 1998, pp. 557-559
Citations number
10
Categorie Soggetti
Clinical Neurology",Pediatrics
Journal title
ISSN journal
08830738
Volume
13
Issue
11
Year of publication
1998
Pages
557 - 559
Database
ISI
SICI code
0883-0738(1998)13:11<557:IPIITT>2.0.ZU;2-K
Abstract
We treated seven patients with subacute sclerosing panencephalitis wit h beta-interferon and oral inosiplex for 2 to 15 months. Stabilization or improvement was observed in three patients. The effect of treatmen t was equivocal in two other patients who became stable. The disease c ontinued its progression in the remaining two patients who died. Treat ment shorter than 2 months was not effective. Changes in electroenceph alograms (EEG), magnetic resonance images (MRI), or cerebrospinal flui d measles antibody levels did not have a close correlation with clinic al course. These results suggest that beta-interferon might be efficie nt in some patients with subacute sclerosing panencephalitis and justi fy its trial in larger studies with longer follow-up.