INOSITOL LEVELS IN POST-MORTEM BRAIN SAMPLES OF ALZHEIMERS PATIENTS

Authors
AGAM G SHIMON H SHAPIRO J DAVIDSON M HAROUTUNIAN V
Citation
G. Agam et al., INOSITOL LEVELS IN POST-MORTEM BRAIN SAMPLES OF ALZHEIMERS PATIENTS, Progress in neuro-psychopharmacology & biological psychiatry, 22(8), 1998, pp. 1241-1250
Citations number
34
Categorie Soggetti
Neurosciences,"Clinical Neurology","Pharmacology & Pharmacy",Psychiatry
Journal title
Progress in neuro-psychopharmacology & biological psychiatry → ACNP
ISSN journal
02785846
Volume
22
Issue
8
Year of publication
1998
Pages
1241 - 1250
Database
ISI
SICI code
0278-5846(1998)22:8<1241:ILIPBS>2.0.ZU;2-M
Abstract
1. Free inositol levels in occipital and parietal cortex of Alzheimer' s Disease (AD) patients were reported to be significantly elevated by 10-35% compared with matched controls, studied by magnetic resonance s pectroscopy (MRS) during life. 2. An MRS study of post mortem samples failed to demonstrate a significant difference between AD and controls . 3. The present study shows non-significant trends of 13% increase in frontal cortex and 5% and 21% decrease in occipital cortex and cerebe llum respectively, in post mortem brain specimens of AD patients measu red gas chromatographically (GC).