SUSTAINED REMISSION OF SEVERE RESISTANT AUTOIMMUNE NEUTROPENIA WITH CAMPATH-1H

We report the course of a patient with severe autoimmune neutropenia i n whom only transient responses occurred with corticosteroids, antilym phocyte globulin granulocyte-colony stimulating factor, and who was re sistant to treatment with azathioprine, cyclosporin and intravenous im munoglobulin. A 10d course of intravenous Campath-1H monoclonal result ed in a sustained haematological response. The long-lasting effect of Campath-1H may be due to its remarkable ability to induce a profound a nd prolonged peripheral blood T lymphopenia.